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Netrin-1

Netrin-1 Overview

English Name	Netrin 1	Approved Drugs	0
Drugs in Clinical Trials	1	Target Synonym	Netrin-1，Netrin 1， Mouse， Homolog Of，MRMV4，Epididymis tissue protein Li 131P，NTN1L
Highest Development Stage	Phase 2 Clinical

English Name	Netrin 1
Target Synonym	Netrin-1，Netrin 1， Mouse， Homolog Of，MRMV4，Epididymis tissue protein Li 131P，NTN1L
Approved Drugs	0
Drugs in Clinical Trials	1
Highest Development Stage	Phase 2 Clinical

Netrin-1 Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag (1)
Conjugate
Unconjugated (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
NE1-H52H3	Human	HEK293	Human Netrin-1 Protein, His Tag

Total: 1

Netrin-1 Background

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

Netrin-1 Synonyms

Netrin-1,NTN1,NTN1L,Netrin1,netrin 1

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
NP-137	NP-137; NP-137R; NP137P	Phase 2 Clinical	Netris Pharma, Centre Leon Berard	Solid tumours; Pancreatic Neoplasms; Endometrial Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms	Details