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FAP
FAP Overview
| English Name | Prolyl endopeptidase FAP | Approved Drugs | 0 |
| Drugs in Clinical Trials | 45 | Target Synonym | Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | Prolyl endopeptidase FAP |
| Target Synonym | Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 45 |
| Highest Development Stage | Phase 3 Clinical |
FAP Product List
- Product Category
Protein (13)Beads (1)Cell (1)
- Product Status
Launched (15)
- Species
Human (9)Cynomolgus (2)Mouse (2)Rat (1)Canine (1)
- Tag
Fc Tag (2)His Tag (7)His Tag & Avi Tag (4)- (2)
- Conjugate
Unconjugated (5)FITC Labeled (2)Biotin-labeled (4)PE Labeled (1)- (2)AF647 Labeled (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT FAP-H5244 |  Human | HEK293 | Human FAP Protein, His Tag, active dimer, low endotoxin (MALS verified) |  |  |  |
HOT FAP-H5263 | Human | HEK293 | Human FAP Protein, Fc Tag, active dimer, low endotoxin (MALS verified) |  | | |
HOT FAP-H82Q6 | Human | HEK293 | Biotinylated Human FAP Protein, His,Avitag™, active dimer (MALS verified) |  | | |
HOT FAP-M52H3 |  Mouse | HEK293 | Mouse FAP Protein, His Tag, active dimer (MALS verified) |  | | |
CHEK-ATP184 | Human | HEK293 | HEK293/Human FAP Stable Cell Line |  | ||
FAP-HA243 | Human | HEK293 | Alexa Fluor™ 647-Labeled Human FAP Protein, His Tag |  | | |
FAP-HF243 | Human | HEK293 | FITC-Labeled Human FAP Protein, His Tag |  | | |
FAP-HF263 | Human | HEK293 | FITC-Labeled Human FAP Protein, Fc Tag |  | | |
FAP-HP245 | Human | HEK293 | PE-Labeled Human FAP Protein, His Tag (Site-specific conjugation) |  | | |
MBS-K077 | Human | - | Human FAP-coupled Magnetic Beads |
Total: 15
- 1
- 2
FAP Background
FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
FAP Synonyms
FAP,FAPalpha,SIMP,Seprase,APCE
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| [18F]fibronstatin | 18F-LNC1005 | Phase 3 Clinical | Yantai Lanna Cheng Biotechnology Co Ltd | Solid tumours; Stomach Neoplasms; Diagnostic agents | Details |
| Talabostat | VbP; PT-100; BXCL-701 | Phase 2 Clinical | Point Therapeutics | Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma; Melanoma; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms, Germ Cell and Embryonal; Neoplasm Metastasis; Carcinoma, Pancreatic Ductal; Carcinoma, Small Cell; Lung Neoplasms; Leukemia, Myeloid, Acute; Prostatic Neoplasms; Kidney Neoplasms; Sarcoma; Neuroblastoma; Neuroendocrine Tumors; Central Nervous System Neoplasms; Pancreatic Neoplasms; Myelodysplastic Syndromes; Skin Neoplasms; Ovarian Neoplasms; Liver Neoplasms; Solid tumours | Details |
| 68Ga-TCR-FAPI | 68Ga-TCR-FAPI | Phase 2 Clinical | Tumor Research Institute Chinese Academy Of Medical Sciences | Neoplasms; Medullary thyroid cancer (MTC) | Details |
| NTI-1309 | NTI-1309; LNTH-1363S; 64Cu-LNTH-1363S | Phase 2 Clinical | Noria Therapeutics Inc | Esophageal Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Sarcoma; Colorectal Neoplasms | Details |
| AAA-614 | AAA-614; FAP-2286; Lu-FAP-2286 | Phase 2 Clinical | Novartis Ag | Solid tumours; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung | Details |
| 177Lu-EB-FAPI | 177Lu-EB-FAPI | Phase 2 Clinical | Zhejiang University | Pancreatic Neoplasms; Cholangiocarcinoma; Carcinoma, Pancreatic Ductal | Details |
| 177Lu-DOTA-EB-FAPI | Phase 2 Clinical | The First Affiliated Hospital Of Xiamen University | Solid tumours; Adenocarcinoma, Follicular; Thyroid Neoplasms; Thyroid Cancer, Papillary | Details | |
| [18F]FAPI-74 | FAPI-74; [18F]FAPI-74; Fluor-18-FAPI-74; F-18]FAPI-74 | Phase 2 Clinical | University Of Heidelberg | Ovarian Neoplasms; Biliary Tract Neoplasms; Pheochromocytoma; Stomach Neoplasms; Dermatomyositis; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms | Details |
| 68Ga-FAP-2286 | 68-Ga-FAP-2286; 68Ga-FAP-2286 | Phase 2 Clinical | 3B Pharmaceuticals GmbH | Solid tumours; Neoplasm Metastasis | Details |
| 68Ga-FAPI-46 | [68Ga]FAPI-46; 68Ga-FAPI-46 | Phase 2 Clinical | Karolinska University Hospital | Neoplasms; Carcinoma, Hepatocellular; Alveolitis, Extrinsic Allergic; Pneumoconiosis; Carcinoma, Pancreatic Ductal; Bile Duct Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Pulmonary Fibrosis; Lung Diseases, Interstitial; Carcinoma, Ovarian Epithelial; Adenomatous Polyposis Coli; Pancreatic Neoplasms; Pneumonia; Stomach Neoplasms; Esophageal Neoplasms; Metabolic Dysfunction-Associated Steatotic Liver Disease; Radiation Pneumonitis; Idiopathic Interstitial Pneumonias; Ovarian Neoplasms | Details |
| 177Lu-FAP-2286 | 177Lu-FAP-2286 | Phase 2 Clinical | 3B Pharmaceuticals GmbH | Solid tumours | Details |
| RO-7122290 | RO-7122290; RG-7827 | Phase 2 Clinical | F. Hoffmann-La Roche Ltd | Colorectal Neoplasms | Details |
| NG-641 | EnAd-FAP-BiTE; EnAd-FAP-Tac; NG-641; NG-aFAP | Phase 1 Clinical | Akamis Bio Ltd, University Of Oxford | Squamous Cell Carcinoma of Head and Neck; Neoplasms, Glandular and Epithelial; Neoplasm Metastasis | Details |
| Simlukafusp alfa | FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Carcinoma, Renal Cell; Breast Neoplasms; Uterine Cervical Neoplasms; Melanoma | Details |
| CD137/FAP bispecific agonist antibody (Boehringer Ingelheim International) | Phase 1 Clinical | Boehringer Ingelheim International Gmbh | Neoplasms | Details | |
| 68Ga-PNT-6555 | Phase 1 Clinical | Point Biopharma Inc | Solid tumours; Esophageal Neoplasms; Sarcoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Melanoma | Details | |
| 68Ga-FAPI-XT-117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details | |
| 64Cu-FAPI-XT117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details | |
| OMTX-705 | OMTX-705 | Phase 1 Clinical | Oncomatryx Biopharma Sl | Solid tumours | Details |
| MP-0310 | MP-0310; AMG-506 | Phase 1 Clinical | Molecular Partners Ag, Amgen Inc | Solid tumours | Details |
| 68Ga-NI-FAPI | 68Ga-NI-FAPI | Phase 1 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| 177Lu-FAPI-RGD | 177Lu-FAPI-RGD | Phase 1 Clinical | Peking Union Medical College Hospital | Neoplasms | Details |
| 177Lu-JH04 | 177Lu-JH04 | Phase 1 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| Lutetium [177Lu]-FAP-75 | Lutetium [177Lu]-FAP-75 | Phase 1 Clinical | Fudan University | Solid tumours | Details |
| 18F-LNC1007 | 18F-LNC1007 | Phase 1 Clinical | Yantai Lanna Cheng Biotechnology Co Ltd | Solid tumours; Neoplasms; Diagnostic agents | Details |
| 68Ga-JH04 | 68Ga-JH04; JH-04 | Phase 1 Clinical | Bivision Pharmaceuticals Inc | Neoplasms | Details |
| 68Ga-FAPI-JH04 | 68Ga-FAPI-JH04 | Phase 1 Clinical | First Affiliated Hospital Of Fujian Medical University | Neoplasms | Details |
| 68Ga-PSFA | 68Ga-PSFA | Phase 1 Clinical | First Affiliated Hospital Of Chongqing Medical University | Adenomatous Polyposis Coli | Details |
| 68 Ga-OncoFAP-DOTAGA | 68 Ga-OncoFAP | Phase 1 Clinical | Blue Earth Diagnostics, Philochem | Solid tumours | Details |
| 18F-AlF-FAPi-04 | 18F-AlF-FAPi-04 | Phase 1 Clinical | Affiliated Hospital Of North Sichuan Medical College | Solid tumours | Details |
| 177Lu-EB-FAPI(Peking Union Medical College Hospital) | 177Lu-EB-FAPI(Peking Union Medical College Hospital) | Phase 1 Clinical | Peking Union Medical College Hospital | Neoplasm Metastasis | Details |
| 68Ga-FAPI(Peking Union Medical College Hospital) | 68Ga-FAPI(Peking Union Medical College Hospital) | Phase 1 Clinical | Peking Union Medical College Hospital | Neoplasm Metastasis | Details |
| [177Lu]Lu-XT117 | [177Lu]Lu-XT117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details |
| RTX-1363-S | RTX-1363S; RTX-1363-S | Phase 1 Clinical | Ratio Therapeutics Inc | Stomach Neoplasms; Pancreatic Neoplasms; Breast Neoplasms; Lung Neoplasms | Details |
| 68Ga/64Cu-FAPI-XT117 | 68Ga/64Cu-FAPI-XT117 | Phase 1 Clinical | Beijing Xiantong International Technology Co Ltd | Solid tumours | Details |
| 177Lu-LNC1004 | 177Lu-LNC1004; 177Lu-LNC-1004 | Phase 1 Clinical | Yantai Lanna Cheng Biotechnology Co Ltd | Solid tumours | Details |
| 68Ga-FAPI-RGD | 68Ga-FAPI-RGD; 68Ga-LNC-1007 | Phase 1 Clinical | Peking Union Medical College Hospital, Fujian Medical University | Carcinoma, Renal Cell; Neoplasms; Lung Neoplasms | Details |
| SHR-7367 | SHR7367; SHR-7367 | Phase 1 Clinical | Shanghai Hengrui Pharmaceutical Co Ltd | Solid tumours; Neoplasms | Details |
| 177Lu-PNT6555(Point Biopharma) | PNT-6555 | Phase 1 Clinical | Point Biopharma Inc | Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Sarcoma; Cholangiocarcinoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal | Details |
| RO-7300490 | RO-7300490; RG-6189; FAP-CD40; FAP-huCD40 | Phase 1 Clinical | F. Hoffmann-La Roche Ltd | Solid tumours | Details |
| anti-BCMA/NKG2DL/FAP TCR T-cell therapy (Guangdong VitaLife) | Clinical | Multiple Myeloma | Details | ||
| 177Lu-BRP-010 | BRP-010; 177Lu-BRP-010 | Clinical | BoomRay Pharmaceuticals Co Ltd | Solid tumours | Details |
| 68Ga-BRP-010 | BRP-010; 68Ga-BRP-010 | Clinical | BoomRay Pharmaceuticals Co Ltd | Solid tumours | Details |
| [90Y] YFAPI-46 | Clinical | German Cancer Consortium (Dktk), University of Duisburg-Essen | Solid tumours | Details | |
| 3BP-3940 | 3BP-3940 | Clinical | Johannes Gutenberg University Of Mainz, 3B Pharmaceuticals GmbH | Neoplasms | Details |
Product Reviews
W***I2025-11-07
0People LikeACRO's human protein FAP-H5244 has very good activity, fast shipment, good packaging, and is quite sensitive during experiments. Will repurchase for future experiments.
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